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What to Watch Tonight: The Season 3 Premiere of Marvel's Agents of S.H.I.E.L.D., and the Debuts of Grandfathered and The Grinder

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What to watch on Tuesday, September 22...

12:01am, Hulu
The Mindy Project
Mindy tries to keep maternity exciting in “Leo Castellano Is My Son,” which ultimately leads to a quarrel with Danny. Elsewhere, Tamra blabs the gossip about Jeremy’s new squeeze (Cristin Milioti).

SERIES PREMIERE, 8pm, Fox
Grandfathered
John Stamos stars as Jimmy, a tomcatting restaurant owner who suddenly learns that he’s both a father and a grandfather. The multigenerational antics begin with Jimmy’s grown son Gerald (Josh Peck) arriving with his baby daughter in tow. Paget Brewster and Ravi Patel also star.

8pm, ABC
The Muppets
In “Hostile Makeover,” Kermit tries to patch things up with Piggy by fixing her up with Josh Groban, who incidentally has some thoughts on rejiggering her talk show. Meanwhile, Fozzie is invited to Jay Leno’s house party, and Bobo pesters the staff by hawking cookies for his daughter’s troop.

8pm, CBS
NCIS
The team tackles a perplexing case for a DEA agent who shares a tragic history with Gibbs in “Personal Day.” On the NCIS Fashion Watch, Gibbs’s new business-casual appearance raises eyebrows.

8pm, The CW
iHeartRadio Music Festival
Kanye West, Sam Smith, Coldplay, Demi Lovato, and Duran Duran are among the performers featured in the first of two shows highlighting the Las Vegas concert. Part two airs tomorrow night, because The CW’s got another whole week to fill before launching its premieres.

SERIES PREMIERE, 8:30pm, Fox
The Grinder
Rob Lowe portrays a hotshot actor who goes to work at his family’s law firm after his long-running legal drama wraps. The pilot finds him returning to his hometown of Boise and immediately clashing with younger brother Fred Savage.

8:30pm, ABC
Fresh Off the Boat
After Nicole breaks Eddie’s heart in “Boy II Man,” he finds solace in the soulful strains of Boyz II Men’s hit single “End of the Road.” This prompts a puzzled Jessica to consult Honey for parenting advice.

SEASON 3 PREMIERE, 9pm, ABC
Marvel’s Agents of S.H.I.E.L.D.
Coulson and the team deal with both a new Inhuman and another organization on the lookout for superpowered people. Elsewhere in “Laws of Nature,” a stricken Fitz takes drastic measures in his quest to learn what’s become of Simmons. (Geez, Fitz, just check last year’s season finale. It’s right there on Netflix for Pete’s sake!)

9pm, Fox
Scream Queens
Chanel takes on Hester as a project in “Chainsaw,” while Chanel No. 3 unburdens her conscience. Among people not named Chanel, Denise targets a Kappa, Grace and Zayday espy a connection between two students, and Chad and Earl Grey round up a frat posse to hunt down the Red Devil.

9pm CBS
NCIS: New Orleans
A blogger known for shining a light on government corruption is murdered in “Shadow Unit,” and the investigation leads the team to a cover-up involving a Navy/CIA humanitarian mission in Bolivia.

NOT A NEW TIME, 10pm, NBC
Best Time Ever With Neil Patrick Harris
The live variety show shifts to the family hour, possibly to better accommodate the cast and crew’s bedtimes. UPDATE: Actually it doesn't, at least not this week, because NBC lives to torment me.

10pm, CBS
Limitless
“Badge! Gun!” finds Brian jeopardizing his new FBI gig when he pokes his nose into the investigation of a journalist’s murder, against orders. Note to FBI brass: Don’t hire the lead characters of a network TV procedural to help solve your crimes if you don’t want a loose cannon who gets results, dammit!

10pm, FX
The Bastard Executioner
Lady Love sets off for Windsor to ask King Edward II of Ventrishire’s fate in “A Hunger / Newyn.” Meanwhile, Baron Pryce pays a visit of his own to Castle Ventris.

10pm, BET
Real Husbands of Hollywood
In “Kevin Davis Jr.,” Kevin is offered the chance to star in a biopic about Sammy Davis Jr. Somewhere, ‘80s Billy Crystal is fuming.

10:30pm, Comedy Central
Drunk History
In “Cleveland,” the Anti-Saloon League fights for Prohibition, Dorothy Fuldheim fights her way to the top of TV news, and Muhammad Ali refuses to fight in the Vietnam War. The decidedly non-teetotaling performers include Gaius Charles, Samm Levine, Mary Elizabeth Ellis, George Wallace, and Ron Funches

LATE-NITE:
– Joseph Gordon-Levitt, Ike Barinholtz, and Andrew McMahon on Conan, 11pm, TBS
– Bumble founder and CEO Whitney Wolfe on The Daily Show with Trever Noah, 11pm, Comedy Central
– Michelle Buteau and Cenk Uygur on The Nightly Show With Larry Wilmore, 11:30pm, Comedy Central
– Julianne Moore, Mark-Paul Gosselaar, and DNCE on The Tonight Show Starring Jimmy Fallon, 11:35pm, NBC
– Ellen Page, Jesse Eisenberg, and inventor Dominic Wilcox on Late Show with Stephen Colbert, 11:35pm, CBS
– Viola Davis, Michael Peña, and Slightly Stoopid on Jimmy Kimmel Live, 11:35pm, ABC
– Kenan Thompson, Maura Tierney, and chef John Besh on Late Night with Seth Meyers, 12:35am, NBC
– Zachary Levi on The Late Late Show with James Corden, 12:37am, CBS

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