The 66-year-old departed due to illness after being unwell for a few days, Channel 5 said.
Angie Bowie in the diary room (Channel 5)
On Monday, American producer David Gest left the house due to medical reasons, which saw Bowie demanding to follow him.
She began packing her suitcase and said in the diary room: “I want to leave now. Get me my stuff. Give me my stuff. Now!”
A Channel 5 spokesman said: “After being unwell for a few days, Angie Bowie has decided to leave the Celebrity Big Brother house. Her exit will be addressed in tonight’s live show on Channel 5 at 9pm.”
Bowie demanded to leave the show (Channel 5)
The other housemates could hear her yelling from the diary room as she shouted: “I am not staying here another minute. Get me out of here right now.”
Despite Big Brother’s concerns that it was the 'middle of the night' and that things 'had to be put in place', she insisted: “Get me a car and let me be gone, if you want to be cheap get me an Uber.”
Gest had taken to his bed over the weekend and left the show after he informed Big Brother he was too ill to continue.
In the diary room, he said: “I’ve been so sick, and I’m really sad as I wish I could stay. It’s something I will never forget.
David Gest also quit the house due to illness (Channel 5)
“I want to thank all the people that have been supporting me, I want to tell all the cast mates that I love them and I love this country for their support and being so good to me. Thank-you Big Brother.”
A tweet from his official account, made by his team, said: “Sorry guys but @DavidGest2016 is a bit poorly just now! When he is all fixed we will let ya know xx.”
— Big Brother UK (@bbuk) January 18, 2016
Gest was at the centre of a row in the house last week when US reality star Tiffany Pollard thought he was the David who had died, instead of David Bowie.
Also last week, Kim Kardashian’s good friend Jonathan Cheban quit the house, citing its 'bad vibe'.
Cheban told Big Brother in the diary room: “I just think that my time here is kind of expired. The house is not fun any more.”