She is the daughter of Moroccan Jewish immigrants. She is bilingual in English and French.
Chriqui began acting as a 10-year-old in a McDonald's commercial. She moved to Vancouver in the mid-1990s, guest-starring in series such as Are You Afraid of the Dark?, Forever Knight, Once a Thief and Psi Factor: Chronicles of the Paranormal. Her first Hollywood role was as a supporting character in Detroit Rock City (1999). Chriqui later appeared in several movies, such as 100 Girls, Wrong Turn, On the Line and In the Mix. She played Eve in the 2005 comedy National Lampoon's Adam & Eve, and played Adam Sandler's love interest in the 2008 film You Don't Mess with the Zohan.
Chriqui was nominated for a Best Actress DVD Exclusive Award for her performance in 100 Girls and was nominated, with Lance Bass, for a Choice Liplock Teen Choice Award in On the Line. In April 2008, she won the Standout Performance Trophy at the Young Hollywood Awards.
Chriqui also starred in Hinder's "Lips of an Angel" music video as well as in the Zac Brown Band's "Whatever It Is" music video. She threw out the ceremonial first pitch at a Los Angeles Dodgers game on June 8, 2008. Chriqui was on the cover of the Autumn 2008 issue of Naked Eye.
She appeared in the 2008 film Cadillac Records as Revetta Chess, where she performed with Beyoncé Knowles. Chriqui was seen in 2009 as one of several women whose lives interconnect in the comedy Women in Trouble and appeared in its 2010 sequel Elektra Luxx.