Eliza Coupe is an American comedic actress from Plymouth, New Hampshire.

Eliza is of French heritage.

In 2007, Coupe appeared in I Think I Love My Wife. She went on to appear in the short-lived MTV series Short Circuitz and on the eighth episode of the first season of Flight of the Conchords, entitled "Girlfriends", as well as an episode of Unhitched. She was a series regular in HBO's unaired 12 Miles of Bad Road and had a recurring role in Samantha Who?.

She had a recurring role as Dr. Denise "Jo" Mahoney in Season 8 of the TV series Scrubs and the companion web series Scrubs: Interns. She was made a regular in Scrubs' Season 9.

In March 2009, Coupe was cast as Callie in the ABC pilot, No Heroics, an adaptation of the UK series of the same name. Coupe played the female lead in the independent film Shanghai Calling, filmed in Shanghai, China. Coupe also appeared in the 2011 movie What's Your Number? with Anna Faris and Chris Evans.

From April 2011 to May 2013, Coupe starred on the ABC ensemble comedy series Happy Endings alongside Elisha Cuthbert, Zachary Knighton, Adam Pally, Damon Wayans, Jr. and Casey Wilson. Despite critical acclaim and a cult following, the show was cancelled by ABC after concluding its third season on May 3, 2013. Since Happy Endings cancellation, Coupe played a recurring role in the third season of House of Lies and currently stars alongside Jay Harrington in the USA Network comedy series Benched, which premiered on October 28, 2014.