In 2005, Zhu joined the MTV China and hosted music programs on China's domestic MTV network. Zhu was discovered by talent scouts after winning a local singing contest in Beijing, then placing third at the national level.
Zhu signed with music label MBOX in 2007 and her first album was released in 2009.
In 2012, Zhu played the character Qi Qi in an American martial arts film The Man with the Iron Fists, alongside RZA, Russell Crowe, Cung Le, Lucy Liu, Byron Mann, Rick Yune, David Bautista, and Jamie Chung.
After playing minor roles in various films, Zhu received her first leading role in a series called Great Mr. Zhou. She earned critical acclaim for this performance and began to get roles in larger scale productions.
In 2014, Zhu starred in a supporting role in the romantic comedy film The Old Cinderella, produced by Lu Chuan. She played the female lead in the film Last Flight, opposite Ed Westwick and featuring Leon Lee and Cary Alexander.
Zhu can currently be seen playing the role of "Kokachin" in the Netflix TV series Marco Polo.