She has appeared in numerous magazines all over the world as a model, including Cosmopolitan magazine in two separate 8-page editorials within the same issue. Scrofano is known for her work on Robocop, Saw VI, and Nurse 3D. She played the roles of Rebecca on Being Erica, October on Pure Pwnage, Suzanna on Gangland Undercover, and Tia Tremblay on The Listener. This year Scrofano will star as Wynonna Earp on the Syfy Tv series Wynonna Earp. Melanie can next be seen playing the role of Veronica Selvaggio on the A&E TV series Damien.